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DR. AMBROSE AGWEYU

DR. AMBROSE AGWEYU
Principal Investigator
Research groups:
Biography
Ambrose is a paediatrician and epidemiologist and the outgoing head of the Epidemiology and Demography Department. His research career spans more than ten years in clinical epidemiology, pragmatic clinical trials, evidence synthesis and clinical guideline implementation. Working closely with the Kenya Ministry of Health, his early research involved conducting systematic reviews for the first national exercise to adapt the WHO paediatric clinical practice guidelines using the GRADE methodology. Following this, Ambrose was the Principal Investigator on a pragmatic clinical trial to study the effectiveness of alternative antibiotics for childhood pneumonia whose findings contributed to a major revision in the Kenyan guidelines. Building on this work, he led a successful grant application jointly awarded by the UK MRC, DFID, NIHR and Wellcome Trust to undertake a large study comparing antibiotic treatments and supportive care strategies in critically-ill children. Ambrose also leads Supportive Care and Antibiotics for Severe Pneumonia among Hospitalised Children (SEARCH) A Pragmatic Randomized Controlled Trial.
Alongside this trial, he currently leads the Clinical Information Network. Ambrose has forged strong links with Government and other national and international institutions. He sits on the Child Health Expert Panel for the Ministry of Health in Kenya providing technical advice to the Ministry on Child Health priorities including immunisation, nutrition, and case management. He is also co-chair of the WHO/UNICEF Child Health Accountability Tracking (CHAT) Technical Advisory Group – a 12-member team with global representation convened to develop a standard set of harmonised indicators for tracking Child Health. As a member of the Kenya Paediatric Association, Ambrose is actively involved in advocacy, medical education and mentorship on how best to implement approaches for the prevention and management of the leading causes of morbidity and mortality in children.
He currently leads the Clinical Information Network – a multi-site implementation science project aimed at promoting quality of clinical documentation, research, and implementation of recommended newborn and paediatric care practices in 19 Kenyan hospitals and one in Tanzania. Ambrose has forged strong links with Government and other national and international institutions. He sits on the Child Health Expert Panel for the Ministry of Health in Kenya providing technical advice to the Ministry on Child Health priorities including immunisation, nutrition, and case management. He is also co-chair of the WHO/UNICEF Child Health Accountability Tracking (CHAT) Technical Advisory Group – a 12-member team with global representation convened to develop a standard set of harmonised indicators for tracking Child Health. As a member of the Kenya Paediatric Association, Ambrose is actively involved in advocacy, medical education and mentorship on how best to implement approaches for the prevention and management of the leading causes of morbidity and mortality in children.
Amoxicillin equivalent to parenteral antibiotics in the treatment of resource-deficient infants with tachypnea
Agweyu, A.
J Pediatr. 2015; : 778-9
Oral amoxicillin versus benzyl penicillin for severe pneumonia among kenyan children: a pragmatic randomized controlled noninferiority trial
Agweyu, A., Gathara, D., Oliwa, J., Muinga, N., Edwards, T., Allen, E., Maleche-Obimbo, E., English, M.
Clin Infect Dis. 2015; : 1216-24
Experience developing national evidence-based clinical guidelines for childhood pneumonia in a low-income setting–making the GRADE?
Agweyu, A., Opiyo, N., English, M.
BMC Pediatr. 2012; : 1
Building Learning Health Systems to Accelerate Research and Improve Outcomes of Clinical Care in Low- and Middle-Income Countries
English, M., Irimu, G., Agweyu, A., Gathara, D., Oliwa, J., Ayieko, P., Were, F., Paton, C., Tunis, S., Forrest, C. B.
PLoS Med. 2016; : e1001991
An unsupported preference for intravenous antibiotics
Li, H. K., Agweyu, A., English, M., Bejon, P.
PLoS Med. 2015; : e1001825
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