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Prof. Tom Williams

Prof. Tom Williams

Principal Investigator

Research groups:


Tom is Professor of Haemoglobinopathy Research at Imperial College, London. Tom has worked in Kilifi since May 2000, where he now directs a programme of human genetic research with a focus on polymorphisms of the red blood cell. He obtained his medical degree at Westminster Medical School in the University of London in 1985 and subsequently trained in Paediatrics and Tropical Medicine at a range of London hospitals including Westminster Children’s Hospital, University College, the Hospital for Tropical Diseases and Imperial College. He obtained his PhD on the genetics of malaria resistance in children, from the University of London in 1999. He has published extensively on the burden and clinical consequences of red cell genetic disorders and their relationship with malaria protection, questions which he studies using both laboratory-based and epidemiological approaches.


Currently, his work involves a large-scale phase IV impact study of Pneumococcal Conjugate Vaccine in Kilifi and a multi-site study of the aetiology of pneumonia in children in developing countries. He is working with PATH Vaccines in the clinical development of a whole-cell pneumococcal vaccine and supervises students in the areas of pneumococcal pathogenesis, modeling of pneumococcal transmission and vaccine impact and the role of childhood malaria in the aetiology of hypertension in adults in Kilifi.

High mortality from Plasmodium falciparum malaria in children living with sickle cell anemia on the coast of Kenya

McAuley, C. F., Webb, C., Makani, J., Macharia, A., Uyoga, S., Opi, D. H., Ndila, C., Ngatia, A., Scott, J. A., Marsh, K., Williams, T. N.

Clin Infect Dis. 2015; : 1216-24

The effect of alpha+-thalassaemia on the incidence of malaria and other diseases in children living on the coast of Kenya

Wambua, S., Mwangi, T. W., Kortok, M., Uyoga, S. M., Macharia, A. W., Mwacharo, J. K., Weatherall, D. J., Snow, R. W., Marsh, K., Williams, T. N.

BMC Pediatr. 2012; : 1

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